张洪星,博士,副教授,硕士生导师,长期从事肿瘤相关的小分子生物硫醇、生物活性氧/氮荧光探针的构建以及新型近红外荧光染料的合成工作。近年来,主持国家自然科学基金1项,横向项目1项,省部级项目2项,授权发明专利5项;在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Biomaterials, Chin. Chem. Lett.等国际权威学术期刊共发表SCI论文SCI论文20余篇。指导学生获“微瑞杯”第四届全国大学化学实验创新设计大赛总决赛特等奖(2023年),获第四届全国大学化学实验创新设计大赛“欧倍尔-微瑞杯”西北赛区一等奖(2023年)。
[1] Hongxing Zhang, Jing Liu*, Yuanqiang Sun, Mengxing Liu and Wei Guo*, Carbon–Dipyrromethenes: Bright Cationic Fluorescent Dyes and Potential Application in Revealing Cellular Trafficking of Mitochondrial Glutathione Conjugates, J. Am. Chem. Soc., 2020, 40, 17069.
[2] Mengxing Liu, Jing Liu*, Hongxing Zhang*, Lijuan Wang, Jianan Tao, Wei Guo*, Augmenting heptamethine cyanine photosensitivity while retaining strong fluorescence emission: Forming dye-albumin nanocomplex enables tumor-targeted photodynamic therapy, Chin. Chem. Lett., 2025, 111141.
[3] Hongxing Zhang, Guanlin Lao, Mengxing Liu, Zhihui Jia, Jing Liu*, and Wei Guo*, Excited-State Conjugation/De-Conjugation Driven Nonradiative Thermal Deactivation for Developing Fluorogenic Probes to Diagnose Cancers, Chem. Biomed. Imaging, 2024, 2, 6, 432-441.
[4] Hongxing Zhang, Guoxi Ren, Wenhua Hou, Lijuan Wang, Yuan-Qiang Sun*, and Jing Liu*, A Silicon-Rhodamine-Based Heavy-Atom-Free Photosensitizer for Mitochondria-targeted Photodynamic Therapy, Spectrochim. Acta. A Mol. Biomol. Spectrosc., 2024, 308, 123688.
[5] Yan Song#, Hongxing Zhang#, Xia Wang, Xin Geng, Yuanqiang Sun*, Jing Liu*, and Zhaohui Li, One Stone, Three Birds: pH Triggered Transformation of Aminopyronine and Iminopyronine Based Lysosome Targeting Viscosity Probe for Cancer Visualization, Anal. Chem., 2021, 93, 1786.
[6] Hongxing Zhang, Jing Liu, Bo Hu, Linfang Wang, Z Yang, Xu Han, Juanjuan Wang, Wei Bai, Wei Guo*, Dual-Channel Fluorescence Diagnosis of Cancer Cells/Tissues Assisted by OATP Transporters and Cysteine/Glutathione, Chem. Sci., 2018, 9, 3209.
[7] Hongxing Zhang, Jing Liu, Linfang Wang, Minjia Sun, Xiaohan Yan, Juanjuan Wang, Jianping Guo, Wei Guo*, Amino-Si-rhodamines: A new class of two-photon fluorescent dyes with intrinsic targeting ability for lysosomes, Biomaterials, 2018, 158, 10.
[8] Hongxing Zhang, Jing Liu, Chenlu Liu, Pengcheng Yu, Minjia Sun, Xiaohan Yan, Jian-Ping Guo*, Wei Guo,* Imaging lysosomal highly reactive oxygen species and lighting up cancer cells and tumors enabled by a Si-rhodamine-based near infrared fluorescent probe, Biomaterials, 2017, 133, 60.
[9] Hongxing Zhang, Jing Liu, Yuan-Qiang Sun, Yingying Huo, Yaohua Li, Weizhi Liu, Xiao Wu, Nishu Zhu, Yawei Shi and Wei Guo*, A mitochondria-targetable fluorescent probe for peroxynitrite: fast response and high selectivity, Chem. Commun., 2015, 51, 2721.
[1] 国家自然科学基金青年科学基金,线粒体靶向的水溶性“碳-双吡咯甲烷(Carbodipy)”正离子型荧光染料的设计、合成、光物理性质研究以及在肿瘤光动力治疗方面的应用(2200706),2021/01-2023/12,主持。
[2] 山西省基础研究计划(面上项目),“碳-双吡咯甲烷(Cardipy)”类近红外肿瘤荧光诊断试剂的开发与应用(202403021211019),2024/07-2027/7,主持。
[3] 横向项目,汽油中乙醇的快速检测试剂盒,2020/06-2023/06,主持。
[4] 山西省高等学校创新人才支持计划,水溶性碳-吡咯甲烷染料(Carbodipy)的设计合成及生物影像应用(2019L0109),2019-2021,主持。
[1] 中国发明专利,一种线粒体粘度探针及其制备方法和应用,张洪星、刘景、郭炜,ZL202111028020.6,授权日:2022年5月27日。
[2] 中国发明专利,一种极性荧光探针及其制备方法和应用,张洪星、刘景,ZL202111027991.9,授权日:2022年5月31日。
[3] 中国发明专利,一种荧光探针及其制备方法和应用,张洪星、劳观林、刘景,ZL202210588887.5,授权日:2023年12月26日。
[4] 中国发明专利,一种香豆素半花菁类光敏剂及其制备方法和应用,张洪星、任国玺、刘景,ZL202211599244.7,授权日:2024年03月12日。
[5] 中国发明专利,一种羧酸功能化的香豆素半花菁染料及其制备方法和应用,张洪星、刘景,ZL2023 1 0121084.3,授权日:2024年10月18日。